JASON D. JOSEPHSON

I'm pursuing my PhD in Chemistry at the University of Ottawa, presently developing new tools in bioorthogonal chemistry.
I'm interested in science, philosophy, religion, mathematics, art, and history.

Journal publications

Nitrones in bioorthogonal chemistry applications.
Scott, E.; Josephson, J. D.; Bilodeau, A. D.; Pezacki, J. P. 2026, Submitted for publication.

A nitrone-based in vivo click SHAPE reagent for mapping RNA secondary structure.
Serhan, M.; Josephson, J. D.; Scott, E.; Lundrigan, E.; Uguccioni, S.; Abram, Q. H.; Sagan, S. M.; Pezacki, J. P. 2026, Submitted for publication.

Computational and experimental investigations of oxadiazinone reactivity with cyclooctynes and other dienophiles.
Josephson, J. D.; Morrill, K; Bilodeau, D. A.; Nakajima, M.; Pezacki, J. P. 2025, Can. J. Chem.

Machine Learning Enabling the Prediction of Activation Energies of SPAAC.
Josephson, J. D.; Pezacki, J. P.; Nakajima, M. 2025, J. Phys. Org. Chem.

Vol. 38, issue 2 cover art.
Josephson, J. D. 2025, J. Phys. Org. Chem.

Bioorthogonal reactions of oxadiazinones with strained trans-cyclooctenes.
Morrill, K.; Josephson, J. D.; Bilodeau, D. A.; Altamimi, B.; Nakajima, M.; Pezacki, J. P. 2025, J. Phys. Org. Chem.

3-Oxidopyridinium Ions Are Versatile Bioorthogonal Dipoles for Use in Cycloadditions with Cyclooctynes.
Serhan, M.; Josephson, J. D.; Masoud, S. S.; Nakajima, M.; Pezacki, J. P. 2024, Chem. Eur. J.

Optimized Bioorthogonal Non-canonical Amino Acid Tagging to Identify Serotype-Specific Biomarkers in Verotoxigenic Escherichia coli.
Strmiskova, M.; Josephson, J. D.; Toudic, C.; Pezacki, J. P. 2023, ACS Infect. Dis.

Photophysical Properties of Donor-Acceptor Stenhouse Adducts and Their Inclusion Complexes with Cyclodextrins and Cucurbit[7]uril.
Payne, L.; Josephson, J. D.; Murphy, R. S.; Wagner, B. D. 2020, Molecules.

Magazine publications

Note on experience in biochemistry
Josephson, J. D. 2025, Interalia Magazine. Article.

Et al.
Josephson, J. D. 2022, Ottawa Design Club Zine 0004. Prose poetry.

Programs written

CubeContour
Github (2024)
Visualize Gaussian-generated .cube files.

MEpathGUI
Github (1.2.0, 2024) SourceForge (1.1.0, 2022)
PyQT-based GUI for creating energy level (PES/reaction coordinate) diagrams for physical chemistry.

Digital artwork (Behance)

Physical artwork

Formal education

Candidate for PhD in Chemistry, University of Ottawa

Summa cum laude BSc Hons in Biochemistry with Minor in Asian Studies, University of Ottawa, 2021

Last updated Feb 2026